Hi Jay,
It looks like they could clog up with slime, but mine seem to clog up on the top surface with algae. I have algae problems in both my 75 and 125 and until this week the back of the tanks were getting a lot of light from the windows. I just painted the back glass of the tanks to eliminate this light. The algae builds up in about three weeks. The diffuser still works but I notice that the bubbles are larger so I clean the disk then. I think the CO2 encourages algae to form on the disk.
I clean the disk with a 50% bleach solution in a small drinking glass. Its clean in about 20 minutes.
The one thing I like about the Eheim diffuser is that it is small. I compare it to my big reactor which you can see at:
http://users.ev1.net/~spituch/Steve&...O2/DIYco2.html
Talk about a pain-in-the-*ss, this thing is a bear to dissconect to take outside to clean. The view ports at the top and bottom which I use to see the bubbles scum up with brown algae slime and then I can't count the bubbles.
l would rather clean the eheims every few weeks when I wipe the glass clean, than struggle with the bear every couple of months.
Besides, based on the much larger surface area of the smaller bubbles I still disagree with most of the aquarium community and still feel that the diffuser is more efficient than a reactor.