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Livebearers can produce 3 or more litters from one encounter.
Separating males from females will stop the breeding, but the females will continue to produce for a while, then stop. Keep separating the babies as soon as you can tell. All the females can go in one tank, all the males in another.

Having a predator on hand makes things a lot easier. Most fish will eat fry, even if they are not specifically noted as predators.
I have a few Bichers that take care of excess Guppies.
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