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I have, in the heat of battle, dosed as much as 1ml per gallon. In a 55g with substrate and hard scape that's about 45-50 ml max. I ramp up the dose over a weeks time, that gives the enemy time to realize that I'm serious, and hopefully avoids any friendly fire incidents.

I have yet to experience an enemy that could withstand a week of that full artillery barrage. As has been said, aim your weapon directly at the enemy.

At that rate, I do notice a dip in moral of my troops.
 
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